Case of hepatosplenic ?? T-cell lymphoma presenting with severe hypersplenism
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چکیده
منابع مشابه
Hepatosplenic T-cell lymphoma: A case series.
Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of Non-Hodgkin Lymphoma (NHL), grouped under the mature or peripheral T-cell lymphomas. It is characterised by extranodal infiltration and proliferation of malignant T-cells within the sinusoids of the liver, sinuses and red pulp of the spleen, and the bone marrow. The tumour cells express CD2 and CD3, but are CD4, CD5 and CD8 negative and ex...
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Hepatosplenic T-cell lymphoma (HSTCL) is a rare and aggressive extranodal T-cell lymphoma that comprises <5% of peripheral T-cell lymphomas. The majority of cases harbor the γδ T-cell receptor (TCR), but recently, a few cases have been shown to express the αβ TCR. Comparison of these two subtypes (αβ and γδ) shows similar clinicopathologic and cytogenetic features; however, due to the paucity o...
متن کاملHemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report
Hepatosplenic T-cell lymphoma (HSTCL) is a rare non-Hodgkin lymphoma, marked by liver, spleen, and bone marrow sinusoidal infiltration, with an aggressive clinical course, which represents a difficult diagnostic task for clinicians and pathologists. Another equally severe and challenging condition is the hemophagocytic lymphohistiocytosis (also called hemophagocytic syndrome [HS]), which is oft...
متن کاملHepatosplenic T-cell Lymphoma: Case Report & Literature Review
Hepatosplenic T-cell lymphoma (HSTCL) was first described as a distinct clinicopathologic entity in 1990. HSTCL is more common among young males in their teenage years and in young adulthood. It is an aggressive tumor. Our patient presented with pancytopenia, hepatosplenomegaly but no lymphadenopathy. The key role for diagnosis was through identifying of double negative CD4, CD8 negative lympho...
متن کاملLiterature Review : Hepatosplenic T - cell Lymphoma
Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of T-cell lymphoma with poor clinical outcomes. Typical clinical features include a predominance of young male with fever, hepatosplenomegaly and cytopenia with the absence of appreciable lymphadenopathy. Diagnosis is based on examination of peripheral blood and histopathology of bone marrow, spleen or liver. In addition, immunophenotyping an...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1999
ISSN: 0361-8609,1096-8652
DOI: 10.1002/(sici)1096-8652(199904)60:4<313::aid-ajh14>3.0.co;2-g